University College, London.

Lipids are key building blocks of cells that form bilayer membranes with many important roles. Thousands of different lipids are produced by cells but their functions are largely unknown. The goal of this project is to understand how lipids, and especially their side-chains, modulate the structure, dynamics and function of bilayers. This interdisciplinary project will pioneer DNA-based molecular rulers to answer the fundamental question of how lipid length alters the localized bilayer thickness within live cells. As there is no other comparable experimental route, our approach is expected to provide a step-change in understanding of how lipid side-chain diversity shapes bilayers. The Research Associate will work with Prof. Stefan Howorka in the Department of Chemistry at University College London and with Prof. Ulrike Eggert, King’s College London. The postholder will perform research in both laboratories.